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Continuous Infusion of Insulin in Hyperglycemic Low‐Birth Weight Infants Receiving Parenteral Nutrition with and without Lipid Emulsion
Author(s) -
Kanarek Keith S.,
Santeiro Maria L.,
Malone John I.
Publication year - 1991
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/0148607191015004417
Subject(s) - parenteral nutrition , medicine , insulin , gestational age , birth weight , low birth weight , neonatal intensive care unit , regimen , infusion pump , glucose homeostasis , anesthesia , endocrinology , pediatrics , pregnancy , insulin resistance , biology , genetics
The efficiency of a continuous infusion of insulin in improving glucose tolerance was compared in two groups of very low‐birth weight infants (mean ± SEM birth weights 757 ± 40 vs 828 ± 80 g and gestational ages 27.6 ± 0.7 vs. 27.2 ± 0.5 weeks) receiving total parenteral nutrition with and without the addition of lipid emulsion to the nutrition regimen. The mean ± SEM cumulative doses of insulin (0.87 ± 0.1 vs 1.15 ± 0.3 U/kg) and hours required to decrease the blood glucose level to 120 mg/dL (9.1 ± 0.8 vs 9.5 ± 1.0 hours) were similar. Insulin was delivered with a syringe pump used for other routine purposes in the neonatal intensive care unit. Continuous intravenous insulin infusion is an effective, inexpensive, safe method for maintaining glucose homeostasis in low‐birth weight infants who develop hyperglycemia as a consequence of total parenteral nutrition. ( Journal of Parenteral and Enteral Nutrition 15 :417–420, 1991)