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Factors Which Regulate Net Hepatic Glucose Uptake In Vivo
Author(s) -
Cherrington Alan D.,
Pagliassotti Michael J.,
Myers Sharon R.,
AdkinsMarshall Bess,
Mcguinness Owen P.
Publication year - 1991
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/014860719101500371s
Subject(s) - glucagon , insulin , medicine , endocrinology , in vivo , hormone , glucose uptake , pancreatic hormone , enteral administration , chemistry , parenteral nutrition , biology , insulin resistance , microbiology and biotechnology
The regulation of net hepatic glucose uptake in vivo occurs by way of the hormonal milieu (insulin and glucagon), the glucose level, and the route of glucose delivery. Hyperglycemia in the absence of changes in pancreatic hormones (i.e., increased insulin and/or decreased glucagon) does not elicit significant glucose uptake by the liver. Net hepatic glucose uptake is augmented in a dose‐dependent manner by a rise in insulin and is further stimulated by the presence of a “portal signal.” The presence of coordinated changes in insulin, glucagon, and the glucose level in combination with the “portal signal” ensures adequate glucose uptake by the liver in response to a meal. ( Journal of Parenteral and Enteral Nutrition 15: 71S‐73S,1991)