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Effect of a Taurine‐Supplemented Diet on Conjugated Bile Acids in Biliary Surgical Patients
Author(s) -
Wang WenYen,
Liaw KoungYi
Publication year - 1991
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/0148607191015003294
Subject(s) - taurine , glycocholic acid , taurocholic acid , bile acid , parenteral nutrition , medicine , gastroenterology , enteral administration , endocrinology , cholic acid , chemistry , biochemistry , amino acid
The effect of a taurine‐supplemented diet on the level of conjugated bile acids in postoperative patients was investigated during two consecutive 5‐day periods. Eighteen hepatobiliary patients with choledochostomies and a specific T‐tube insertion were collected and divided randomly into two groups. In group 1, an ordinary postoperative soft diet was prescribed for the first 5 postoperative days and then followed with a taurine‐supplemented soft diet (40 μmol/kg per day) for 5 consecutive days. In group 2, the taurine‐supplemented diet was prescribed in reverse. At the end of the two periods, on days 5 and 10, bile was collected via a T‐tube with an inflatable balloon and low‐pressure motor suction. Analysis of conjugated bile acids was done by high‐performance liquid chromatography. The results showed that a taurine‐supplemented diet increased the concentration of taurocholic acid, glycocholic acid, taurochenodeoxycholic acid, glycochenodeoxycholic acid, and total bile acid from 0.5, 1.9, 0.3, 1.4, and 4.7 mg/mL (on day 5) to 1.1, 3.5, 1.0, 2.6, and 8.9 mg/mL, respectively, on day 10 in group 1. Similar findings were noted in group 2. These results indicate that a taurine‐supplemented diet may enhance the conjugation and secretion of bile acid in hepatobiliary patients. (Journal of Parenteral and Enteral Nutrition 15 :294–297, 1991)