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Effects of a Fish Oil Diet on Pigs' Cardiopulmonary Response to Bacteremia
Author(s) -
Murray Michael J.,
Svingen Bruce A.,
Holman Ralph T.,
Yaksh Tony L.
Publication year - 1991
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/0148607191015002152
Subject(s) - arachidonic acid , fish oil , thromboxane , medicine , sepsis , omega 3 fatty acid , thromboxane b2 , endocrinology , eicosanoid , omega , fatty acid , chemistry , biology , platelet , biochemistry , polyunsaturated fatty acid , docosahexaenoic acid , fish <actinopterygii> , fishery , enzyme , physics , quantum mechanics
Since an ω3 fatty acid (FA) diet may have beneficial effects in inflammatory processes, we tested the hypothesis that the physiologic response to sepsis could be modified by altering the eicosanoid precursor pool via an ω3 FA diet. Two groups (n = 8) of pigs were prefed for 8 days either an ω3 FA or an w6 FA diet (Weaner Pig Feed with either menhaden or corn oil to produce a eucaloric feed with 15% fat) and then injected with live Escherichia coli. The w3 FA diet increased the concentration of eicosapentainoic acid (EPA, 20:5ω3) in plasma lipids, and increased the ratio of EPA to arachidonic acid (AA, 20:4ω6) in platelets from 1:20 to 1:1 over the 8 days. Following the injection of bacteria, there was a fall in PaO 2 and blood pressure that was attenuated ( p < 0.05) by the ω3 FA diet. The ω3 FA diet, compared to the ω6 FA diet, also attenuated the rise in thromboxane B2 (3.0 ± 1.1 vs 12.9 ± 5.7 ng/mL) and 6 keto‐PGF 1α (0.8 ± 0.5 vs 1.7 ± 1.1 ng/mL) associated with bacteremia. We conclude that dietary ω3 FA attenuated the physiologic response to sepsis, possibly by modifying arachidonic acid metabolism. (Journal of Parenteral and Enteral Nutrition 15: 152–158, 1991)