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Cori Cycle Contribution to Plasma Glucose Appearance in Man
Author(s) -
Hoffer L. John
Publication year - 1990
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/0148607190014006646
Subject(s) - gluconeogenesis , plasma glucose , endocrinology , medicine , chemistry , carbohydrate metabolism , substrate (aquarium) , metabolism , biology , insulin , ecology
The contribution of recycled glucose to gluconeogenesis and plasma glucose appearance (Cori cycle) has previously been calculated from liver balance studies and from infusions of labeled glucose. Both techniques resulted in the estimate that Cori cycle activity accounts for about 15% of plasma glucose appearance. However, it is now understood that the specific activity of gluconeogenic precursors, which is used to determine their contribution to glucose appearance in plasma, overestimates the true precursor specific activity. Using earlier published data on substrate utilization and glucose turnover kinetics in humans, an empiric correction factor of 2.7 is derived which may approximately account for label dilution in the precursor pool. Use of this factor confirms that the former estimate of the contribution of Cori cycle activity to glucose turnover should be revised substantially upwards. (Journal of Parenteral and Enteral Nutrition 14 :646–648, 1990)