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Internal Biliary Drainage, Parenteral Nutrition, and Variation in the Total Parenteral Nutrition Feeding Solutions: Influence on the Healing of Colon Anastomosis in Jaundiced Rats
Author(s) -
Delemarre J.B.V.M.,
Van De Velde C.J.H.,
De Brauw L.M.,
Vree R.,
Giesberts M.,
Hermans J.
Publication year - 1990
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/0148607190014006629
Subject(s) - parenteral nutrition , anastomosis , medicine , enteral administration , gastroenterology , wound healing , jaundice , surgery
The influence of preoperative internal biliary drainage and various types of total parenteral nutrition (TPN) on the healing of a colon anastomosis in 50 jaundiced rats was investigated. Jaundice was induced by division and ligation of the common bile duct. After 5 days a colon anastomosis was made. Ten days thereafter the bursting pressure of the anastomosis was measured as an assessment of wound healing. Bursting pressures were significantly lower in jaundiced rats compared with a sham‐operated nonjaundiced group. Preoperative internal biliary drainage significantly improved bursting pressure (p < 0.001) as did preoperative TPN ( p < 0.001). In the second part of the study the influence of four different feeding solutions on the healing of a colon anastomosis was tested. Solutions with and without 20% fat emulsion and a solution with branched‐chain amino acids were tested as well as glucose only. No significant differences were observed among these four groups on the parameters tested. (Journal of Parenteral and Enteral Nutrition 14 :629–633, 1990)