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Manganese Levels in a Jaundiced Long‐Term Total Parenteral Nutrition Patient: Potentiation of Haloperidol Toxicity?: Case Report and Literature Review
Author(s) -
Mehta Rehka,
Reilly James J.
Publication year - 1990
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/0148607190014004428
Subject(s) - toxicity , parenteral nutrition , manganese , medicine , cholestasis , enteral administration , gastroenterology , jaundice , pharmacology , chemistry , organic chemistry
Manganese is vital in human nutrition. When oral intake is precluded, the recommended parenteral supplementation is 0.15 to 0.8 mg/day. Manganese is excreted primarily in the bile; during cholestasis, serum manganese levels may rise, and manganese toxicity ensue. Neuropsychiatric symptoms are prominent. Phenothiazine‐derivative drugs may potentiate manganese toxicity. Serum or whole blood manganese levels should guide manganese therapy in jaundiced patients. ( Journal of Parenteral and Enteral Nutrition 14 :428–430, 1990)