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Gut Glutamine Metabolism
Author(s) -
Souba Wiley W.,
Herskowitz Kenneth,
Salloum Rabih M.,
Chen Mike K.,
Austgen Thomas R.
Publication year - 1990
Publication title -
journal of parenteral and enteral nutrition
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/014860719001400403
Subject(s) - glutamine , metabolism , catabolism , homeostasis , medicine , endocrinology , biology , biochemistry , amino acid
The gut plays a key role in interorgan glutamine metabolism in normal and catabolic states. During critical illness, the gut responds to prevailing metabolic pressures that may result in a temporary "reset" in interorgan glutamine flow. As the body recovers from the disease process, the alterations in gut glutamine metabolism revert to normal, which helps restore glutamine homeostasis. Overwhelming stresses, such as severe systemic infection, may lead to permanent organ dysfunction and further adaptive changes in glutamine metabolism.