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Nortriptyline Absorption in Short Bowel Syndrome
Author(s) -
Broyles Joyce E.,
Brown Rex O.,
Self Timothy H.,
Frederick Randall C.,
Luther R. Wayne
Publication year - 1990
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/0148607190014003326
Subject(s) - short bowel syndrome , parenteral nutrition , nortriptyline , medicine , gastroenterology , enteral administration , gastrointestinal tract , drug , intensive care medicine , pharmacology , amitriptyline
Severe short bowel syndrome usually requires a period of parenteral nutrition support until gastrointestinal hypertrophy occurs. Because of the shortened length of the gastrointestinal tract, oral drug therapy can be compromised secondary to decreased absorption. In the case presented, a patient with short bowel syndrome who required parenteral nutrition was able to achieve therapeutic nortriptyline serum concentrations while receiving the drug via the oral route. (Journal of Parenteral and Enteral Nutrition 14:326–327,1990)