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The Effect of High Lipid Diet on In Vitro Prostaglandin E2 and Thromboxane B2 Production by Splenic Macrophages
Author(s) -
Ogle Cora K.,
Tchervenkov Jean,
Alexander J. Wesley,
Ogle James D.,
Palkert Diane,
Taylor Ann,
Barnwell Sheryl,
Warden Glenn D.
Publication year - 1990
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/0148607190014003250
Subject(s) - linoleic acid , prostaglandin e2 , thromboxane b2 , in vitro , endocrinology , medicine , thromboxane , prostaglandin , macrophage , chemistry , biology , biochemistry , fatty acid , platelet
Feeding animals a diet high in linoleic acid for 7 days had no effect on the in vitro production of PGE 2 by unstimulated macrophages. Feeding animals the high linoleic acid diet for 30 days greatly increased the production of PGE 2 by macrophages when they were unstimulated, but decreased the production of PGE 2 when they were stimulated with LPS. Feeding animals a diet high in linoleic acid for 30 days increased the production of TxB 2 by macrophages when they were unstimulated, but decreased the production of TxB 2 when they were stimulated. Normal, unstimulated splenic macrophages produced almost 80 times more TxB 2 than PGE 2 . However, when the macrophages were stimulated the ratio decreased to six or less because of a greater increase in PGE 2 production. The high linoleic acid diet did not inhibit the antibody dependent cellular cytotoxicity of macrophages. (Journal of Parenteral and Enteral Nutrition 14: 250–254, 1990)