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Serum vitamin A and E concentrations in pediatric total parenteral nutrition patients
Author(s) -
Hack SL,
Merritt RJ,
Morgan RM,
Keefe MT
Publication year - 1990
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/0148607190014002189
Subject(s) - parenteral nutrition , medicine , gastroenterology , vitamin , fat soluble vitamin , endocrinology
There is uncertainty as to optimal doses of fat soluble vitamins required by pediatric total parenteral nutrition (TPN) patients. We compared serum vitamin A (A) and E (E) concentrations analyzed by HPLC in chronic (greater than 2 weeks) TPN patients aged 1 month to 12 years to values obtained in out‐patient surgery patients of the same age. TPN patients received 1500 micrograms of retinol and 2.5 IU of E as alpha‐tocopheryl acetate (2.5 ml LyphoMed Multi Vitamin Concentrate). These doses were 214% of the recommended dose of A and 36% for E. Oral intake was minimal in most patients. The results of our study revealed a mean serum A level for TPN patients (N = 29) of 26.0 +/‐ 15.0 (SD) micrograms/dl vs 25.0 +/‐ 10.0 (SD) micrograms/dl in controls (N = 52). Mean serum E was 0.63 +/‐ 0.24 (SD) mg/dl vs 0.89 +/‐ 0.31 (SD) mg/dl for TPN patients and controls, respectively. There was no consistent trend related to duration of TPN for 23 patients with serial values. Seven (24%) TPN patients had serum A greater than mean + 2 SD of control (p less than 0.01). No values were less than mean ‐ 2 SD. Infants on TPN had a significantly lower mean serum A (22.3 +/‐ 10.9 micrograms/dl) than TPN patients greater than 1 year of age (34.1 +/‐ 16.0 micrograms/dl; p less than 0.001). Fifty‐two percent of TPN patients vs 26% of control had serum A less than 20 micrograms/dl (p greater than 0.1). For E, one patient had a high value and two patients low values relative to control.(ABSTRACT TRUNCATED AT 250 WORDS)