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Effect of fat infusions on platelet concentration in premature infants
Author(s) -
Spear ML,
Spear M,
Cohen AR,
Pereira GR
Publication year - 1990
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/0148607190014002165
Subject(s) - fat emulsion , parenteral nutrition , medicine , platelet , enteral administration , adverse effect , critically ill , infant formula , anesthesia , pediatrics
Critically ill premature infants often require lipid emulsions with parenteral nutrition until enteral feedings can be safely initiated. Because thrombocytopenia has been listed as a potential side effect of fat emulsions, we examined the effect of varying doses of intravenous fat infusions on platelet concentrations in premature infants. An initial validation study demonstrated no artifactual effect of fat infusions on the electronic cell counter method of platelet enumeration. We observed no adverse effect of fat emulsions administered at doses of 0.8 to 3.3 g/kg/day on platelet concentration either during short‐term (48 hr) or long‐term study periods (4 weeks).