Premium
The Absence of the Diet‐Derived 7‐Deazapurine, Queuine in Artificial Liquid Diets
Author(s) -
Reyniers Jon P.,
Katze Jon,
Farkas W.R.
Publication year - 1989
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/0148607189013005542
Subject(s) - parenteral nutrition , biochemistry , guanine , cancer , transfer rna , enteral administration , biology , chemistry , medicine , rna , nucleotide , genetics , gene
Queuine is a derivative of guanine found in the transfer RNAs of most organisms including man. Higher mammals cannot synthesize queuine and must obtain it either from their diets or intestinal microflora. Tumor cells often contain much less queuine in their transfer RNAs than do normal cells. Cancer patients are frequently fed artificial liquid diets or are nourished by chemically defined intravenously administered liquids. In this report we present the results of our examination of five common artificial nutrition preparations obtained from a hospital pharmacy with respect to their content of queuine. (Journal of Parenteral and Enteral Nutrition 13: 542–544,1989)