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Serial Plasma and Urinary Aluminum Levels and Tissue Loading in Preterm Twins
Author(s) -
Bozynski Mary Ellen A.,
Sedman Aileen B.,
Naglie Ronald A.,
Wright Eileen J.
Publication year - 1989
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/0148607189013004428
Subject(s) - urinary system , parenteral nutrition , creatinine , medicine , endocrinology , enteral administration , liter , aluminium , kidney , chemistry , organic chemistry
Serial plasma, urinary, and postmortem tissue aluminum levels were determined in 32‐week, appropriate‐forgestational‐age twins from 45 to 151 days postnatal age. Estimated total aluminum absorptions were 56.7 mg, and 28 mg, twin A and twin B, respectively. At autopsy, Twin A had a hypoplastic right kidney while Twin B had normal kidneys. Mean plasma aluminum levels (twin A, 34.2 μg/liter and twin B, 32.3 μg/liter) and urinary aluminum levels expressed as aluminum creatinine ratios (twin A, 11.3 and twin B, 8.5) were similar. These levels were elevated compared to normal plasma aluminum levels of 5.1 ± 3.6 (1 SD) and urinary aluminum creatinine ratios of 0.64 ± 0.75 (1 SD). Twin A had higher tissue aluminum levels than twin B in all tissues except for brain. Bone and liver aluminum contents for both twins were increased as compared to infants receiving short‐term or no parenteral nutrition. We conclude; (1) tissue aluminum loading occurs in infants receiving aluminum‐containing solutions, (2) plasma and urinary aluminum levels are poor predictors of tissue aluminum content, (3) enteral solutions may add significant aluminum exposure. (Journal of Parenteral and Enteral Nutrition 13: 428–431, 1989)