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Remission Induction in Refractory Crohns Disease Using a High Calorie Whole Diet
Author(s) -
Afdhal N.H.,
Kelly J.,
Mccormick P.A.,
O'Donoghue D.P.
Publication year - 1989
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/0148607189013004362
Subject(s) - refractory (planetary science) , medicine , calorie , disease , low calorie , pediatrics , gastroenterology , intensive care medicine , food science , biology , astrobiology
Eleven patients with severe refractory Crohns disease were treated with a high calorie, whole diet. Eight patients achieved remission with a drop in DAS from 13 to 4 ( t = 6.31, p < 0.001) and reversal of subacute obstruction in all cases. Nutritional parameters including weight, triceps skinfold thickness, arm muscle area, and serum albumin increased in all patients. The diet was well tolerated with a mean treatment period of 20 days. Clinical relapse of disease occurred in all cases within 9 months (mean 6 ± 2 months). The mechanism of action of a high calorie diet (HCD) is unclear and warrants further study but antigen or specific food exclusion does not appear to be required as judged by this study. ( Journal of Parenteral and Enteral Nutrition 13: 362–365, 1989)