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Preliminary Studies of a Dicarboxylic Acid as an Energy Substrate in Man
Author(s) -
Mingrone G.,
Tacchino R.M.,
Greco A.V.,
ArcieriMastromattei E.,
Marino F.,
Finotti E.,
Castagneto E.
Publication year - 1989
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/0148607189013003299
Subject(s) - respiratory quotient , palmitic acid , azelaic acid , clearance , chemistry , urine , carbon dioxide , substrate (aquarium) , respiratory system , parenteral nutrition , lactic acid , chromatography , fatty acid , medicine , biochemistry , organic chemistry , biology , ecology , genetics , bacteria , urology
Azelaic acid (Az), a straight saturated chain nine carbon dicarboxylic acid, was administered in saline form to six healthy male volunteers by iv route. Serum levels of Az and urinary amounts of both azelaic and pimelic (C7) acids were measured by an improved gas liquid chromatographic method. Stoichiometric analysis of Az metabolism was compared with that of glucose and palmitic acid. The respiratory quotient (RQ) as well as the ATP/CO 2 ratio of Az were quite similar to that of palmitic acid. Therefore, Az oxidation is associated with a low cost of ATP synthesis in terms of carbon dioxide production. At the infusion rate used (7.5 g/hr) more than 50% of the administered dose was excreted in the urine. However, the remaining portion was cleared from the plasma in 200 min suggesting an uptake by body tissues which was also confirmed by indirect calorimetric analysis. ( Journal of Parenteral and Enteral Nutrition 13 :299–305, 1989)