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Impact of Fat and Glucose Administration on Metabolic and Respiratory Interactions in Sepsis
Author(s) -
Giovannini Ivo,
Chiarla Carlo,
Boldrini Giuseppe,
Castagneto Marco
Publication year - 1989
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/0148607189013002141
Subject(s) - parenteral nutrition , sepsis , respiratory system , medicine , enteral administration , intensive care medicine
Metabolic and respiratory interactions were analyzed in a large group of septic patients (S) and in a reference group of nonseptics (NS) during the iv administration of glucose and fat. In spite of a moderate increase in CO 2 production (VCO 2 ) observed during the administration of fat in S, a VCO 2 ‐sparing effect of fat, with respect to equicaloric amounts of glucose, was reconfirmed. The relevance of the therapeutic modulation of CO 2 production during parenteral nutrition, and the relative impact on the abnormal septic respiratory patterns, were emphasized by analyzing the physiological relationships and mechanisms responsible for the increase in respiratory work in sepsis. ( Journal of Parenteral and Enteral Nutrition 13 :141–146, 1989)