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Stability and Delivery of Vancomycin Hydrochloride When Admixed in a Total Parenteral Nutrition Solution
Author(s) -
Schilling Craig G.,
Watson David M.,
McCoy Harry G.,
Uden Donald L.
Publication year - 1989
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/014860718901300163
Subject(s) - vancomycin , parenteral nutrition , liter , medicine , catheter , chromatography , chemistry , surgery , biology , staphylococcus aureus , bacteria , genetics
Vancomycin hydrochloride, 400 mg/liter was mixed in six standard pediatric parenteral nutrition solutions with and without heparin added. The solutions were stored over a period of 8 days (192 hr) under refrigeration and at room temperature. Aliquots from all six solutions were assayed in duplicate for vancomycin at time 0, 24, 96, and 192 hr. All samples were run through an Ivex 0.22‐micron filter, observed for physical incompatibilities, and frozen at —70°C until assay. Our results indicate that vancomycin was stable and was delivered with loss in concentration of less than 5% with and without storage under refrigeration. This study suggests an alternative method for delivering vancomycin when treating a catheter‐related infection. If vancomycin is delivered in this fashion, less manipulations of the line would be required. In addition, there may be a theoretical advantage of constantly bathing the catheter with vancomycin when the catheter is suspected of harboring the infecting organism. (Journal of Parenteral and Enteral Nutrition 13 :63–64, 1989)