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Alteration of Erythrocyte Lipid Composition following Total Parenteral Nutrition in the Rat
Author(s) -
Innis Sheila M.
Publication year - 1989
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/014860718901300147
Subject(s) - parenteral nutrition , phospholipid , sphingomyelin , phosphatidylcholine , cholesterol , medicine , lecithin , soybean oil , chemistry , endogeny , emulsion , lipid emulsion , endocrinology , biochemistry , biology , membrane
Rats were infused continuously for 7 days with a complete total parenteral nutrition (TPN) solution in which 27.5% total calories were given as a parenteral lipid emulsion containing soybean oil (Liposyn) or safflower oil (Intralipid) emulsified with egg phospholipid (PL). Compared to sham‐operated rats fed chow, the erythrocyte membranes from rats given TPN with lipid emulsion had increased cholesterol and PL but normal molar cholesterol:PL ratios. The fatty acid changes in sphingomyelin and phosphatidylcholine, in particular, suggested replacement of endogenous PL with the exogenous egg PL infused with the emulsion. The changes in membrane lipid composition were accompanied by greater resistance of the cells from rats given TPN to osmotic lysis in vitro. (Journal of Parenteral and Enteral Nutrition 13:47–50, 1989)