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Effect of Phototherapy Light, Sodium Bisulfite, and pH on Vitamin Stability in Total Parenteral Nutrition Admixtures
Author(s) -
Smith J.L.,
Canham J.E.,
Wells P.A.
Publication year - 1988
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/0148607188012004394
Subject(s) - riboflavin , sodium bisulfite , bisulfite , chemistry , vitamin , liter , multivitamin , parenteral nutrition , chromatography , food science , biochemistry , medicine , organic chemistry , gene expression , dna methylation , gene
The three sections of this study extend previous research into losses of vitamins A, C, E, thiamin, riboflavin, and folic acid from total parenteral nutrition (TPN) admixtures. First, phototherapy light on TPN admixtures containing one of four amino acid solutions was studied. Experimental conditions included presence or absence of Intralipid iv fat emulsion, plastic bag or glass bottle storage container, and storage time of up to 48 hrs. The second phase studied stability of the same vitamins (except vitamin E) for 48 hrs in admixtures containing the amino acid solution which has no bisulfite, in glass bottles; with or without Intralipid; and with added sodium bisulfite (final concentrations of 0, 1, 2, 3, 4, 5 and 10 mEq/liter). Third, vitamin C and thiamin levels were measured in admixtures containing the amino acid solution with no bisulfite, without Intralipid, stored in glass bottles with various bisulfite concentrations (0, 1, 2, or 3 mEq/liter) and three pH levels (5.5, 6.5, and 6.75 pH). Exposure of TPN admixtures to phototherapy light caused losses of vitamins A, C, and riboflavin. Intralipid inclusion significantly reduced losses of vitamin A and riboflavin, but did not appear to affect vitamin C levels. The smallest vitamin C losses were noted in admixtures containing amino acid solutions A or B. Phototherapy light did not affect thiamin levels. Bisulfite had no affect on vitamin C, riboflavin, or folic acid levels. Vitamin A levels were maintained with bisulfite concentrations less than 3 mEq/liter. At 3 mEq/liter bisulfite, admixtures with Intralipid showed 50% loss of vitamin A. Significant losses of thiamin were noted at bisulfite concentrations of 3 mEq/liter and higher after 24 hrs, with or without Intralipid. Vitamin C loss was more pronounced as pH increased, especially at low bisulfite concentrations. Thiamin levels decreased as bisulfite concentration increased at 5.5 pH, but at higher pH thiamin levels were unchanged. (Journal of Parenteral and Enteral Nutrition 12 :394–402, 1988)