Premium
Tissue Levels of Vitamin E (α‐Tocopherol) in Response to Continuous Intravenous Multivitamin Infusion
Author(s) -
Gutcher Gary R.
Publication year - 1988
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/0148607188012002152
Subject(s) - multivitamin , medicine , vitamin , enteral administration , weanling , bolus (digestion) , vitamin e , tocopherol , parenteral nutrition , lung , endocrinology , chemistry , antioxidant , biochemistry
Weanling rats were made vitamin E deficient over a 10‐week course. Vitamin E was then provided at 4 IU/ kg/day as a continuous infusion of the α‐tocopherol in Berocca PN. Tissue samples of heart, lung, liver, and perinephric fat and plasma were analyzed for vitamin E levels at 24 and 72 hr. Compared to experimental controls that received a rat chow containing 372 IU/g mixed tocopherol, normal levels were achieved in the test group within 24 hr in plasma and liver. Lung and heart muscle levels were within the normal range by 24–72 hr, although significantly below the control level; fat levels did not normalize. Continuous infusion of vitamin E as tocopherol in a multivitamin preparation results in normal tissue levels in lung and liver in a fashion similar to that achieved by previously described methods of single bolus intravenous infusion or repeated subcutaneous injection. ( Journal of Parenteral and Enteral Nutrition 12 :152–154, 1988)