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Effect of Nucleotide Restriction and Supplementation on Resistance to Experimental Murine Candidiasis
Author(s) -
Fanslow William C.,
Kulkarni Anil D.,
Van Buren Charles T.,
Rudolph Frederick B.
Publication year - 1988
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/014860718801200149
Subject(s) - nucleotide , medicine , resistance (ecology) , biology , microbiology and biotechnology , genetics , gene , ecology
The influence of dietary nucleotides on susceptibility to candidiasis in mice was studied using two criteria: animal survival and recovery of viable Candida albicans organisms from the kidney and spleen. One‐month‐old mice were placed on one of five diets with varying nucleotide content. The results show that mice maintained on a nucleotide‐free diet (NF) exhibit a significantly decreased mean survival time and a significantly increased viable organism recovery in the spleen following intravenous injection of graded inocula of C. albicans compared to mice fed diets containing RNA or uracil as a nucleotide source. (Journal of Parenteral and Enteral Nutrition 12:49–52, 1988)