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The Effect of Different Intravenous Nutritional Regimens on Renal Function during Acute Renal Failure in the Rat
Author(s) -
Freund Herbert R.,
MuggiaSullam Michael,
Lafrance Richard,
Holroyde Jane,
Edwards Laura L.,
Fischer Josef E.
Publication year - 1987
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/0148607187011006556
Subject(s) - renal function , fractional excretion of sodium , medicine , hypermetabolism , creatinine , parenteral nutrition , enteral administration , catabolism , endocrinology , acute kidney injury , protein catabolism , amino acid , urology , metabolism , chemistry , biochemistry
Acute renal failure in the surgical patient is accompanied by a state of hypermetabolism and increased catabolism. Nutritional therapy is therefore directed at the preservation of body cell mass and protein synthesis for repair of wounds and damaged renal tubuli and for maintenance of host defense mechanisms. We examined the effect of two levels of protein intake (18.4 ± 1.4 and 30.8 ± 2.4 mg N/100 g BW/ day) and three different amino acid formulations (Freamine III, Nephramine, and a made‐up mixture of Nephramine + Freamine HBC)† on renal function following mercurv chloride‐induced acute renal failure in the rat. All animals suffered severe renal failure manifested by increased plasma urea and creatinine levels, decreased creatinine clearance, and increased fractional excretion of sodium. On day 4 of acute renal failure, rats receiving low dose amino acids had better‐preserved renal function than those receiving high dose amino acids. However, the type of solution infused did not affect recovery of renal function. (Journal of Parenteral and Enteral Nutrition 11: 556–559, 1987)