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Double‐Blind Study of Glycerol vs Glucose in Parenteral Nutrition of Postsurgical Insulin‐Treated Diabetic Patients
Author(s) -
LevRan A.,
Johnson M.,
Hwang D.L.,
Askanazi J.,
Weissman C.,
Gersovitz M.
Publication year - 1987
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/0148607187011003271
Subject(s) - glycerol , insulin , medicine , parenteral nutrition , plasma glucose , diabetes mellitus , regular insulin , endocrinology , hypoglycemia , chemistry , biochemistry
Twenty‐five insulin‐treated diabetic patients were randomly assigned postoperatively to 5 days of intravenous infusions of ProcalAmine (3% amino acids, 3% glycerol, and electrolytes) or FreAmineIII + dextrose and electrolytes. The solutions were given isocalorically and isonitrogenously. Insulin was adjusted to keep glycemia at the level of 150–200 mg/dl. The ProcalAmine group by the 5th day had plasma glucose of 158 ± 25 mg/dl and required 1.20 ± 0.10 U/hr insulin. The FreAmine + dextrose group had plasma glucose of 169 ± 53 mg/dl and required 2.28 ± 0.13 U/hr. At all time points postsurgically, the ProcalAmine group required less insulin. (Journal of Parenteral and Enteral Nutrition 11 :274–274, 1987)