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Close Association of Accelerated Rates of Whole Body Protein Turnover (Synthesis and Breakdown) and Energy Expenditure in Children with Newly Diagnosed Acute Lymphocytic Leukemia
Author(s) -
Kien C. Lawrence,
Camitta Bruce M.
Publication year - 1987
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/0148607187011002129
Subject(s) - basal metabolic rate , protein turnover , protein catabolism , medicine , enteral administration , parenteral nutrition , resting energy expenditure , body weight , basal (medicine) , endocrinology , chronic lymphocytic leukemia , acute lymphocytic leukemia , protein metabolism , metabolism , leukemia , biology , protein biosynthesis , amino acid , lymphoblastic leukemia , biochemistry , insulin
Using a single‐dose [ 15 N]glycine turnover technique, we studied protein metabolism in 15 children with newly diagnosed acute lymphocytic leukemia (ALL). As in our previous study, we observed increased rates of whole body protein synthesis (S) and breakdown (B) in comparison to healthy controls. In eight patients, we assessed basal metabolic rate (BMR). There was a significant linear regression between BMR (kcal/d) (Y) and S (g protein/d) (X): y = 3.7 X + 850 (R = 0.925, p < 0.001). There was also a significant linear correlation between BMR, expressed as a percentage of the normal value, and S expressed as a percentage of the mean value in the healthy children ( r = 0.79, p < 0.05). There were also significant positive correlations between BMR and body weight (r = 0.75, p < 0.05) or age (r = 0.83, p < 0.05) and between S and weight or age (both, r = 0.86, p < 0.01). BMR (kcal/d) also correlated with B (g protein/d) (r = 0.91, p < 0.01). Multiple regression analysis revealed that BMR was much more highly related to S than to weight. These data suggest that increased rates of S are closely related to increased energy requirements in patients with ALL. Furthermore, these data provide evidence for the biological relevance of whole body protein kinetics. ( Journal of Parenteral and Enteral Nutrition 11:129–134, 1987)