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Effects of Infused Intralipids on Neutrophil Chemotaxis during Total Parenteral Nutrition
Author(s) -
Escudier Estelle F.,
Escudier Bernard J.,
HenryAmar Michel C.,
Lobut JeanBruno,
Bernaudin Françoise,
Leclercq Bernard P.,
Nitenberg Gérard M.,
Bernaudin JeanFrancois
Publication year - 1986
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/0148607186010006596
Subject(s) - parenteral nutrition , chemotaxis , medicine , fat emulsion , neutrophile , enteral administration , lipid emulsion , gastroenterology , intensive care medicine , inflammation , receptor
A number of previous studies have suggested that the fat emulsion, Intralipid, might compromise human host defenses, due mainly to impairment of neutrophil functions. The aim of this study was to evaluate the effects of Intralipid on neutrophil chemotaxis in cancer patients receiving total parenteral nutrition including 500 ml of 20% Intralipid over 6 hours (83 ml/hr). No impairment of neutrophil chemotaxis was found during or after lipid infusion. Further investigations are necessary to determine whether, in routine clinical practice, intralipids are responsible for impairment of other neutrophil functions and whether side treatments have a protective effect for neutrophil functions. (Journal of Parenteral and Enteral Nutrition 10:596–598, 1986)