Premium
Aluminum in Parenteral Nutrition Solution—Sources and Possible Alternatives
Author(s) -
Koo Winston W.K.,
Kaplan Lawrence A.,
Horn Jack,
Tsang Reginald C.,
Steichen Jean J.
Publication year - 1986
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/0148607186010006591
Subject(s) - multivitamin , chemistry , sodium , calcium , potassium , magnesium , ascorbic acid , zinc , liter , parenteral nutrition , vitamin , nuclear chemistry , chromatography , inorganic chemistry , biochemistry , food science , medicine , organic chemistry
The extent of aluminum (Al) contamination in parenteral nutrition (PN) solutions for infants is not known. Aluminum was measured in 136 samples from various commercially available components that are used with PN. Results showed Al content varied widely among different components. The same chemical may have a different Al content depending on the manufacturer. However, Al contents were similar among lots from the same manufacturer for the same chemical. Aluminum contamination was arbitrarily classified as high (> 500 μg Al/liter), intermediate (51–500 μg Al/liter) or low (≤ 50 μg Al/liter). The high group included most calcium and phosphorus containing salts, 1 multivitamin preparation, folic acid, ascorbic acid and concentrated (25%) albumin. The intermediate group included sodium lactate, potassium phosphates, zinc and chromium chloride, multitrace metal preparation, and 5% plasma protein. The low group included amino acids, sterile water and dextrose water, chloride salts of sodium, potassium, calcium, copper and chromium, sodium phosphates, magnesium sulphate, zinc sulphate, vitamin B 12 , vitamin K 1 , 1 multivitamin preparation, soybean oil emulsion and heparinized (2 U/ml) saline. PN solutions made from high Al components may contain up to 300 μg Al/liter. Calcium gluconate contributed> 80% of the total Al load from PN. Lowering of Al content in calcium gluconate in addition to use of specific low Al components offers the opportunity to significantly lower the Al concentration of the final PN solution and theoretically may achieve an Al content as low as 12 μg/l. We speculate that Al contamination may occur because Al is present naturally in the chemical substance or added during the manufacturing process. (Journal of Parenteral and Enteral Nutrition 10: 591–595, 1986)