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Postoperative Parenteral Nutrition with High Supply of Branched‐Chain Amino Acids: Effects on Nitrogen Balance and Liver Protein Synthesis
Author(s) -
Kirvelä Olli,
Takala Jukka
Publication year - 1986
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/0148607186010006574
Subject(s) - nitrogen balance , parenteral nutrition , perfusion , amino acid , catabolism , protein catabolism , leucine , protein biosynthesis , medicine , in vitro , in vivo , branched chain amino acid , endocrinology , metabolism , biology , chemistry , biochemistry , nitrogen , microbiology and biotechnology , organic chemistry
Branched‐chain amino acids (BCAA) stimulate muscle and liver protein synthesis in vitro. The significance of this action in catabolic conditions in vivo remains controversial. The effects of a high supply of BCAA in total parenteral nutrition (TPN) on nitrogen balance and liver protein synthesis were studied in a postoperative rat model. After standard operative trauma TPN was commenced with one of two isocaloric programs (I: 20.1% BCAA and II: 50% BCAA) and continued for 48 hr. The relative rate of liver protein synthesis, measured after TPN in vitro by perfusion with 14 C‐leucine, was similar in both groups (I: 53.4 ± 17.3 and II: 49.0 ± 27.3 arbitrary units of synthesis rate, mean ± SD). The cumulative nitrogen balance was positive with both regimens and was not improved by the high supply of BCAA (I: 2.02 ± 0.81 and II: 1.87 ± 0.63 gN/kg/48 hr mean ± SD). We conclude that after moderate surgical trauma TPN with a high supply of BCAA offers no advantage over conventional TPN. (Journal of Parenteral and Enteral Nutrition 10:574–577, 1986)