Premium
Bacterial/Fungal Growth in a Combined Parenteral Nutrition Solution
Author(s) -
Mershon John,
Nogami Wallace,
Williams Janice M.,
Yoder Caryn,
Eitzen Harold E.,
Lemons James A.
Publication year - 1986
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/0148607186010005498
Subject(s) - parenteral nutrition , staphylococcus epidermidis , candida albicans , microbiology and biotechnology , escherichia coli , chemistry , bacterial growth , medicine , staphylococcus aureus , bacteria , biology , biochemistry , genetics , gene
Appropriately mixed, compatible solutions of glucose, amino acids and lipid have recently become available for clinical use. While a single hyperalimentation solution has several advantages over the conventional two‐bottle technique, its effect on infusion‐related septicemia is unknown. An in vitro, mock infusion system identical to that used in our newborn intensive care unit was set up to assess the relative growth rates of three microorganisms in several parenteral nutrition mixtures. Growth of Staphylococcus epidermidis, Escherichia coli and Candida albicans was measured in seven different alimentation solutions, including two combined solutions. Generally, microbial growth was the same or decreased in combined solutions as compared to fat alone although considerably greater than that observed in nonlipid containing solutions. In addition, the ability of these organisms to pass in‐line terminal filters of pore size 0.22 and 1.2 μm was assessed. ( Journal of Parenteral and Enteral Nutrition 10: 498–502, 1986)