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Urea Nitrogen Excretion in Chair‐Adapted Primates
Author(s) -
Dempsey Daniel T.,
Lusk Edward,
Crosby Lon O.,
Melnik George,
Mullen James L.
Publication year - 1986
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/0148607186010004369
Subject(s) - urea , excretion , parenteral nutrition , urine , morning , zoology , meal , enteral administration , medicine , endocrinology , urinary system , chemistry , biology , biochemistry
To evaluate the temporal pattern of urea excretion in chair‐adapted primates (Macaque fascicularis) on continuous total parenteral nutrition (TPN), two groups of five animals were studied. Group I received continuous TPN (75 glucose kcal; 0.56 g nitrogen; and 100 ml fluid per kg per day) while Group II received a single morning isonitrogenous oral meal along with a continuous isovolemic intravenous infusion of 0.45% saline. Urine was collected hourly in group I for 2 days and every 4 hr in group II for 5 days and analyzed for urea content. Time series analysis revealed no periodicity of urea excretion in either group. Six animals were then studied for a total of 46 TPN days to define the relationship between the urea content of a single 3‐hr morning urine aliquot and its respective content in a 24‐hr collection. A significant linear relationship was found ( r = +0.76, p < 0.01). However, using this relationship, a reasonable estimate (±20%) of measured 24‐hr urea output was achieved only 50% of the time using a single 3‐hr urea output. Chair‐adapted primates maintained on continuous TPN or a single oral meal with continuous saline infusion do not exhibit a periodic pattern of urea excretion. The variability in 3‐hr urinary urea output in the chaired primate on continuous TPN does not consistently permit accurate estimation of the coincident 24‐hr urinary urea output. (Journal of Parenteral and Enteral Nutrition 10 :369–374, 1986)