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Hematologic Disorders following Prolonged Use of Intravenous Fat Emulsions in Children
Author(s) -
Goulet O.,
Girot R.,
MaierRedelsperger M.,
Bougle D.,
Virelizier J.L.,
Ricour C.
Publication year - 1986
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/0148607186010003284
Subject(s) - parenteral nutrition , medicine , fat emulsion , bone marrow , enteral administration , histiocyte , gastroenterology , hematologic disorders , platelet , hemophagocytosis , mononuclear phagocyte system , pathology , surgery , pancytopenia
Abnormalities in hematologic parameters, associated with prolonged utilization of intravenous fat emulsion (IVFE), were observed in seven children on long‐term cyclic total parenteral nutrition (TPN). All patients were receiving IVFE (Intralipid 20%) 1 to 2 g/kg/24 hr as part of TPN, during 3 to 18 months. Recurrent thrombocytopenia occurred in all seven patients. Platelet lifespan, as measured with 111 Indium was reduced. Sea‐blue histiocytes containing granulations and hemophagocytosis were seen on bone marrow smears. Scans taken after injection of autologous erythrocytes labeled with technetium‐99 showed bone marrow sequestration of these cells. Taken together, this constellation of hematologic abnormalities suggests that long‐term IVFE administration induces hyperactivation of the monocyte‐macrophage system. ( Journal of Parenteral and Enteral Nutrition 10 :284–288, 1986)