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Serum Concentration of Cobalamines during Total Parenteral Nutrition in Crohn's Disease
Author(s) -
Jacobson Stefan
Publication year - 1986
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/014860718601000219
Subject(s) - parenteral nutrition , liter , medicine , vitamin , enteral administration , gastroenterology , vitamin b12 , cyanocobalamin , regimen , endocrinology , crohn's disease , surgery , disease
The vitamin B 12 status was assessed by measuring the fasting serum (S‐) concentration of cobalamines in a consecutive series of 12 patients with Crohn's disease (CD) given total parenteral nutrition (TPN)—nil per os—for between 21 and 97 days (mean, 49 days). At introduction of TPN the S‐cobalamine concentration was less than 300 pmol/liter in four patients (group I) and more than 300 pmol/liter in eight (group II). Each day during TPN fat‐ and water‐soluble vitamins, including 2 μ g of cyanocobalamin, were given. In group I there was a small increase in the S‐cobalamine level during the first 2 to 4 weeks of TPN, whereas in group II the values approached the middle of the reference range (190–680 pmol/ liter) after 6 to 8 weeks of TPN. It would thus appear that the vitamin regimen studied, including 2 μg of cyanocobalamin per 24 hr, is able to maintain the S‐cobalamine concentration within the reference range during 6 to 8 weeks of TPN in CD patients with no evidence of vitamin B 12 deficiency, and to prevent the development of vitamin B 12 deficiency during 2 to 4 weeks of TPN in CD patients with a S‐cobalamine level initially below 300 pmol/liter. (Journal of Parenteral and Enteral Nutrition 10:223–226, 1986)