Premium
Biotin Deficiency during Total Parenteral Nutrition: Its Clinical Manifestation and Plasma Nonesterified Fatty Acid Level
Author(s) -
Matsusue Satoru,
Kashihara Sadao,
Takeda Hiroshi,
Koizumi Shunzo
Publication year - 1985
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/0148607185009006760
Subject(s) - parenteral nutrition , medicine , fatty acid , endocrinology , gastroenterology , chemistry , biochemistry
We report a case of biotin deficiency developed in a 25‐yr‐old man with Crohn's disease who had been on total parenteral nutrition for more than 9 months. His cutaneous, ophthalmic, and neurologic manifestations were characteristic of this disease entity described in literature. In particular, the appearance of his face deserves to be called “biotin deficiency facies.” After administration of biotin the low plasma nonesterified fatty acid level promptly returned to normal. This phenomenon may prove to serve as a convenient means for the purpose of detecting biotin deficiency. (Journal of Parenteral and Enteral Nutrition 9: 760–763, 1985)