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Acute Gastric Mucosal Lesions—A New Experimental Model and Effect of Parenteral Nutrition
Author(s) -
Nakagawa Kimihiko,
Okada Akira,
Kawashima Yasunaru
Publication year - 1985
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/0148607185009005571
Subject(s) - stomach , medicine , gastroenterology , parenteral nutrition , starvation , gastric mucosa , physiology , pathology
Experiments were performed on 94 male Sprague‐Dawley rats to explore the influence of starvation and parenteral nutrition on the development of acute gastric mucosal changes under stress. Comparative assessments were made of lesions in the gastric mucosa of rats on 1‐ or 6‐day repeated exposure to the stress consisting of restraint with immersion in water. Marked hemorrhagic lesions over the extensive area of the glandular stomach and pronounced ulcerative changes in the nonglandular stomach were observed in 6‐day stress group as compared to 1‐day stress group where only a few hemorrhagic lesions were observed. Thus, this model has proven to provide an excellent experimental model suitable to the purpose of the present investigation. Parenteral nutrition significantly suppressed the development of mucosal damage either in the nonglandular or glandular stomach of rats under 6‐day stress. Furthermore, it has been demonstrated that lesions caused in the glandular stomach increase in severity via exposure to stress and starvation while those evoked in the nonglandular stomach rise in incidence even in the presence of starvation alone. ( Journal of Parenteral and Enteral Nutrition 9: 571–582, 1985)