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Sensitivity and Specificity of Liver Function Tests in the Detection of Parenteral Nutrition‐Associated Cholestasis
Author(s) -
Nanji Amin A.,
Anderson Frank H.
Publication year - 1985
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/0148607185009003307
Subject(s) - cholestasis , alkaline phosphatase , gamma glutamyltransferase , parenteral nutrition , bilirubin , liver function tests , medicine , gastroenterology , liver function , enzyme , biochemistry , biology
We carried out a study to determine which of the liver function tests was the most sensitive and/or specific in detecting parenteral nutrition associated cholestasis. The tests utilized were alkaline phosphatase, γ‐glutamyl transpeptidase, cholyglycine, sulfolithocholylglycine, and bilirubin. Fifty‐nine patients with no prior evidence of liver dysfunction were studied. We found γ‐glutamyl transpeptidase to be the most sensitive (89.5%) and also the least specific (61.9% specificity). Specificity of γ‐glutamyl transpeptidase was improved when it was combined with alkaline phosphatase. We recommend the combination of these two enzymes as the most cost effective way of detecting parenteral nutrition‐associated cholestasis. (Journal of Parenteral and Enteral Nutrition 9: 307–308, 1985)