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Selenium Depletion in Burn Patients
Author(s) -
Hunt Deborah R.,
Lane Helen W.,
Beesinger David,
Gallagher Karen,
Halligan Rekha,
Johnston Dennis,
Rowlands Brian J.
Publication year - 1984
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/0148607184008006695
Subject(s) - parenteral nutrition , medicine , selenium , urine , nutrient , excretion , physiology , glutathione peroxidase , burn injury , gastroenterology , zoology , surgery , intensive care medicine , biology , chemistry , oxidative stress , ecology , catalase , organic chemistry
Victims of major burns may be at risk for selenium (Se) depletion because increased postinjury nutrient needs are often met by total parental nutrition and tube feedings which contain little Se. This study compared Se status of 17 burn patients and 191 healthy control subjects. Se intake of burn patients was lower than the intake of control subjects when total parenteral nutrition or tube feedings were used as primary nutrient sources but was comparable to the control intake when burn patients consumed oral diets. Serial determinations each 10 days during recovery showed that burn patients had lower plasma Se, erythrocyte Se, and erythrocyte glutathione peroxidase levels, and lower 24‐hr urine Se excretion. These results provide biochemical evidence of Se depletion despite exogenous Se intake within the range recommended for healthy adults. Further studies are indicated to determine if Se depletion in burn patients can be prevented by Se supplementation of total parenteral nutrition and tube feeding solutions. (Journal of Parenteral and Enteral Nutrition 8: 695–699, 1984)