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Bleeding Disorder from the “Fat Overload” Syndrome
Author(s) -
Campbell A.N.,
Freedman Melvin H.,
Pencharz P.B.,
Zlotkin S.H.
Publication year - 1984
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/0148607184008004447
Subject(s) - clearance , parenteral nutrition , platelet , phagocytosis , medicine , fat emulsion , gastroenterology , endocrinology , surgery , immunology , urology
The fat overload syndrome developed in a 7‐yr‐old girl receiving total parenteral nutrition with 20% Intralipid. She developed a bleeding disorder characterized by severe hematemesis that appeared to be due to abnormal platelet function associated with platelet phagocytosis of lipid demonstrable by electron microscopy. The platelet defect and bleeding reversed when the lipemia cleared. ( Journal of Parenteral and Enteral Nutrition 8 :447–449, 1984)