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Relationships between Serum Total Iron‐Binding Capacity and Transferrin
Author(s) -
Crosby Lon O.,
Giandomenico Albert,
Forster Jameson,
Mullen James L.
Publication year - 1984
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/0148607184008003274
Subject(s) - total iron binding capacity , serum iron , hemoglobin , medicine , hematocrit , radial immunodiffusion , endocrinology , chemistry , immunology , antibody
The relationship between serum transferrin (TFN) and serum total iron‐binding capacity (TIBC) in a clinical setting was evaluated in two related studies. The initial study evaluated 101 blood samples representing a cross‐section of hospitalized adults. The samples were double assayed for TIBC using clinical and research methodologies. TFN was assayed by a commercial radial immunodiffusion method. Clinical laboratory TIBC correlated well with research laboratory TIBC (r = 0.87, slope = 0.97, p < 0.001, n = 50) and the relationship of TIBC to TFN yielded the following equation: TFN = 0.83 TIBC — 5.6 (r = 0.82, p < 0.001, n = 101) where TFN = mg/100 ml and TIBC = μ g/100 ml. The second study evaluated a new TIBC assay and its effect on the TIBC/TFN relationship. Additionally, the TFN‐TIBC relationship was evaluated at low normal and abnormal TIBC levels. In this second study, TFN = 1.0 TIBC ‐ 18.8 (r = 0.88, p < 0.01, n = 126). Subsample analysis for specimens with TIBC between 105 and 160 showed a TIBC‐TFN regression line that was not significantly different than the entire sample. Inclusion of ancillary patient data such as hemoglobin and hematocrit did not improve the relationship between TFN and TIBC in either study. The relationship was unaffected by age, sex, race, disease, treatment, fever, surgery, degree of nutritional support, blood transfusion, or blood chemistry parameters in either study. Laboratories deriving TFN from measured TIBC as a nutritional status indicator must determine the relationship for the specific procedures being used in their laboratories. ( Journal of Parenteral and Enteral Nutrition 8: 274–278, 1983)