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Effects of Amino Acid Additives during Hemodialysis of Children
Author(s) -
Abitbol Carolyn L.,
Ozinska Krystyna,
Mandel Susan,
Mcvicar Melinda,
Wapnir Raul A.
Publication year - 1984
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/014860718400800125
Subject(s) - amino acid , dialysis , hemodialysis , chemistry , nitrogen , nitrogen balance , chromatography , medicine , biochemistry , organic chemistry
The intradialytic losses into the dialysate of free amino acids (AA) and α‐amino nitrogen were determined during the dialysis of three children. Variations in plasma AA were determined pre‐ and postdialysis. The effect of these losses with the addition of an Abbott General Amino Acid Mixture to the dialysate in concentrations of 8.5, 17, and 34 mg/100 ml was studied. The major determinant of AA losses was the plasma concentration of the AA before beginning the dialysis treatment. Dialysance of individual AA varied inversely with their molecular weights. A zero flux of α‐amino nitrogen occurred at a derived concentration of 22 mg/100 ml of the AA additive in the dialysate. Plasma concentrations of nonessential amino acids were little affected by the dialysate additive. In contrast, total essential amino acid nitrogen which fell during baseline dialyses showed significant improvement when the AA solution was added to the dialysate. This study suggests that the addition of AA to the dialysate bath may be effective in decreasing AA nitrogen losses during dialysis. (Journal of Parenteral and Enteral Nutrition 8 :25–29, 1983)