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Utilization of Exogenous Fat Emulsion (Intralipid) in Septic Rats
Author(s) -
Wei Jao Chen
Publication year - 1984
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/014860718400800114
Subject(s) - fat emulsion , parenteral nutrition , triglyceride , sepsis , emulsion , medicine , chemistry , septic shock , endocrinology , biochemistry , cholesterol
Utilizations of exogenous fat emulsion (Intralipid) in control, early septic, and late septic rats were studied. After intravenous infusion of 14 C‐Intralipid, cumulative amounts of 14 CO 2 in the expired breath in the 6‐hr period were 42.8 ± 1.8, 35.0 ± 1.8, and 28.5 ± 1.6% of the injected dose, respectively, for the three groups. The amount and the maximum rate of CO 2 production correlated with the severity of sepsis. Significantly greater amounts of plasma triglyceride and free fatty acids were also observed in septic rats. The hyperlipemia associated with the observed decrease in plasma clearance of lipids may account for the decreased utilization of exogenous fat in septic rats. (Journal of Parenteral and Enteral Nutrition 8 :14–17, 1983)