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The Effect of Increasing Total Parenteral Nutrition on Protein Metabolism
Author(s) -
Ang S.D.,
Leskiw M.J.,
Stein T.P.
Publication year - 1983
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/0148607183007006525
Subject(s) - parenteral nutrition , enteral administration , metabolism , protein metabolism , medicine , protein catabolism , concomitant , fat emulsion , protein biosynthesis , glycine , chemistry , zoology , endocrinology , biochemistry , biology , amino acid
We asked the question, if the amount of nutrients given parenterally is progressively increased, does the rate of whole body protein synthesis rate increase correspondingly and how does the protein breakdown rate change? Eight malnourished patients requiring total parenteral nutrition (TPN) were studied. We measured their whole body protein synthesis and breakdown rate four times at intervals of 3 days using 15 N glycine as the tracer. The first study was done pre‐TPN. The 2nd, 3rd, and 4th studies were done at increasing TPN rates. The rates were TPN 1, 1440 kcal/day and 7.9 g/N/ day; TPN 2, 2160 kcal/day and 11.9 g/N/day; TPN 3, 2880 kcal/day and 15.8 g/N/day. The protein synthesis rate initially increased as the amount of TPN was increased, but increasing the rate from TPN‐2 to TPN‐3 did not result in further increase. Increasing the rate of TPN above a certain level does not lead to a concomitant increase in the protein synthesis rate. (Journal of Parenteral and Enteral Nutrition 7 :525–529, 1983)