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Iron Supplementation of Total Parenteral Nutrition: A Prospective Study
Author(s) -
Norton J.A.,
Peters M.L.,
Wesley R.,
Maher M.M.,
Brennan M.F.
Publication year - 1983
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/0148607183007005457
Subject(s) - parenteral nutrition , medicine , hemoglobin , serum iron , sepsis , total iron binding capacity , prospective cohort study , gastroenterology , iron status , iron deficiency , anemia , surgery
A prospective study to evaluate the iron dosage needed to restore serum iron levels was performed on patients receiving prolonged total parenteral nutrition (TPN). Intravenous iron intakes of 0, 25, 87.5, and 175 mg/wk were sequentially studied. No untoward responses were seen in 42 patients studied for 2758 patient days. When compared to pre‐TPN levels, serum iron levels increased significantly with increasing iron dosage (p < 0.002). In every single patient at the two highest dosage levels, serum iron levels at 3 wk rose from the pre‐TPN level. Hemoglobin, reticulocyte count, transfusion requirement, total iron binding capacity, and red cell indices were not affected by iron dosage. There was no increased incidence of sepsis in patients who received increasing iron dosage. Both the 87.5 and 175 mg/wk iron doses increased serum iron levels from pre‐TPN values, but the highest dose increased serum iron levels above the normal range in 80% of patients after 3 wk of administration allowing us to recommend the 87.5 mg/wk dose. ( Journal of Parenteral and Enteral Nutrition 7 :457–461, 1983)