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Nutritional Efficacy and Hepatic Changes during Intragastric, Intravenous, and Prehepatic Feeding in Rats
Author(s) -
King Walter W.K.,
Boelhouwer Roelof U.,
Kingsnorth Andrew N.,
Ross Jeffrey S.,
Young Ver R.,
Malt Ronald A.
Publication year - 1983
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/0148607183007005443
Subject(s) - parenteral nutrition , body weight , albumin , medicine , endocrinology
The nutritional efficacy and hepatic changes in rats given a total parenteral nutrition (TPN) solution consisting of 4.25% amino acids and 25% dextrose by intragastric, intravenous, or prehepatic routes were studied over a 4‐day period. Rats fed Purina Chow or given intragastric TPN maintained body weight and showed no appreciable fatty change of liver. In contrast, weight loss, hepatomegaly, and a 37% increase in liver lipid content were observed in rats given intravenous TPN and a 60% increase after prehepatic TPN. Approximately half the rats given intravenous or prehepatic TPN developed fatty changes in the liver. Serum albumin concentration and hepatic protein content were not improved after prehepatic TPN. Serum SGOT and SGPT were elevated in rats given prehepatic TPN only. Prehepatic TPN may result in hepatic injury and offers no apparent benefit over conventional intravenous TPN in rats. (Journal of Parenteral and Enteral Nutrition 7: 443–446, 1983)