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Reversal of Biochemical and Functional Abnormalities in Erythrocytes Secondary to Selenium Deficiency
Author(s) -
Baker Susan S.,
King Walter W.K.,
Michel Luc,
Wood William C.,
Malt Ronald A.,
Cohen Harvey J.
Publication year - 1983
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/0148607183007003293
Subject(s) - selenium , glutathione peroxidase , pentose phosphate pathway , hexose , selenium deficiency , glutathione , shunt (medical) , medicine , biochemistry , endocrinology , chemistry , enzyme , glycolysis , organic chemistry
A patient with multiple enterocutaneous fistulae on total parenteral nutrition for 14 months developed low erythrocyte selenium and low erythrocyte glutathione peroxidase. Erythrocyte hexose monophosphate shunt activity stimulated with an H 2 O 2 generating system was approximately one‐fourth that of control. Hexose monophosphate shunt activity stimulated with methylene blue showed little difference between patient and control. With selenium supplementation erythrocyte selenium, glutathione peroxidase, and hexose monophosphate shunt activity became normal. Thus, the biochemical and functional consequences of selenium deficiency can be corrected with selenium supplementation.