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Parenteral Nutrition in Anuria of Infancy: Evidence for Sustained Net Protein Synthesis
Author(s) -
Takala Jukka,
Kekomäki Martti
Publication year - 1983
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/014860718300700145
Subject(s) - anuria , parenteral nutrition , dialysis , nitrogen balance , anabolism , methionine , chemistry , urea , medicine , amino acid , blood urea nitrogen , endocrinology , creatinine , biochemistry , nitrogen , organic chemistry
The effects of total parenteral nutrition were studied in two anuric neonates and an anuric infant. Based on the observations of urea production, nitrogen balance, and serum osmolality, the bulk of the infused nitrogen appeared to be incorporated into the body proteins. The need for potassium, calcium, phosphorous, and magnesium substitution was also indicative of net anabolism. Despite effective utilization of the amino acids, high plasma levels of phenylalanine and methionine, and extremely low levels of the urea cycle intermediates were measured. We conclude that the application of carefully planned parenteral nutrition may aid in the management of newborns with failing kidneys and that it influences considerably the indications of dialysis in early infancy.