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Changes in Circadian Rhythmicity of Liver and Serum Parameters in Rats Fed a Total Parenteral Nutrition Solution by Continuous and Discontinuous Intravenous or Intragastric Infusion
Author(s) -
LanzaJacoby Susan,
Sitren Harry S.,
Stevenson Nancy R.,
Rosato Francis E.
Publication year - 1982
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/0148607182006006496
Subject(s) - medicine , endocrinology , circadian rhythm , glycogen , parenteral nutrition , albumin , serum albumin , insulin , body weight , chemistry
Circadian rhythms were assessed in rats (224–246 grams) receiving either an intragastric (IG) or intravenous (IV) infusion continuously (C), or IG or IV infusions discontinuously (D) from 0000 to 1400 hours daily. A control group was maintained on a stock diet ad libitum. IV‐ and IG‐fed rats were infused with 50 milliliters per day of a solution containing 25% dextrose and 4.25% amino acids plus vitamins and minerals. After 10 to 11 days, groups of rats were killed from each treatment every 6 hours over a 24‐hour period. Results showed that IG feeding promoted better growth and nitrogen retention than IV feeding. Rhythm patterns for liver weight, glycogen, and protein content were similar between D‐IG and D‐IV infused rats. All groups except the D‐IV fed rats exhibited fluctuations of serum insulin. A rhythm was not present for serum glucose in C‐IV fed rats and a rhythm was also absent for serum albumin in both C‐IV and D‐IV fed rats. C‐IV feeding increased serum glucose and insulin levels and decreased serum albumin levels in comparison to IG feeding. In comparison to the ad libitum ‐fed, control rats, C‐IV or D‐IV or IG infusions led to alterations in liver and serum parameters.