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Effect of Serum Zinc Level on Amount of Collagen‐Hydroxyproline in the Healing Gut during Total Parenteral Nutrition: An Experimental Study
Author(s) -
Iriyama Keiji,
Mori Takao,
Takenaka Takumi,
Teranishi Tadashi,
Mori Hiroshi
Publication year - 1982
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/0148607182006005416
Subject(s) - zinc , hydroxyproline , parenteral nutrition , medicine , albumin , endocrinology , serum albumin , zinc deficiency (plant disorder) , chemistry , organic chemistry
Changes of serum zinc level in dogs receiving either a zinc‐free solution or a zinc‐supplement solution during total parenteral nutrition (TPN) and the influence of variety of serum‐zinc level on serum albumin and collagen‐hydroxyproline (C‐Hyp) in the incised intestine were investigated. The serum zinc level of zinc‐free dogs that was 126.0 ± 34.3 micrograms per deciliter at the initiation of TPN decreased significantly to 80.0 ± 15.0 micrograms per deciliter during the one week of TPN, whereas that of zinc‐supplement dogs did not decrease during the same period of TPN. Lowering of the serum albumin value was more evident in zinc‐free dogs than in zinc‐supplement dogs. The amount of C‐Hyp in the incised area of the intestine of zinc‐free dogs was 2.63 ± 0.66 micrograms per milligram and that of zinc‐supplement dogs was 4.26 ± 1.04 micrograms per milligram and this difference was significant. It was found that serum zinc level during TPN sharply reflects a supplement of zinc, and C‐Hyp in the incised gut and serum albumin of zinc‐free dogs are lower than those of zinc‐supplement dogs.