Premium
Reduced Metabolic Complications in Total Parenteral Nutrition: Pilot Study Using Fat to Replace One‐third of Glucose Calories
Author(s) -
Meguid Michael M.,
Schimmel Elihu,
Johnson Willard C.,
Meguid Victoria,
Lowell Barbara Cohen,
Bourinski James,
Nabseth Donald C.
Publication year - 1982
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/0148607182006004304
Subject(s) - calorie , parenteral nutrition , medicine , fat emulsion , intensive care medicine
The limitations of glucose‐based TPN solutions are high glucose concentration, high osmolality, lack of fat, and essential fatty acids, which result in glucose intolerance and hepatotoxic effects. We replaced one‐third of the calories in a standard amino acid‐glucose solution with Liposyn 10% for 14 days in 23 critically ill men who needed total parenteral nutrition. Serial measurements included weight, albumin, glucose, triglyceride concentrations, and liver function tests. Serum osmolality was calculated, and found to remain constant. Body weight and serum albumin were maintained. Minor changes occurred in hepatic enzymes which were physiologically insignificant. Glycosuria occurred in 15%. Adverse side effects of hypoglycemia, hyperosmolar coma, and hypertriglyceridemia were avoided. Our results show that the addition of fat reduced glucose and hepatic related metabolic complications.