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A Primate Model for Enteral Nutrition by Tube
Author(s) -
Barot Lenora R.,
Rombeau John L.,
Stein T. Peter,
Chernoff Ronni,
Settle R.G.,
Mullen James L.
Publication year - 1982
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/014860718200600134
Subject(s) - parenteral nutrition , enteral administration , nitrogen balance , jejunostomy , anabolism , medicine , caloric intake , gastrostomy , zoology , body weight , surgery , biology , chemistry , nitrogen , organic chemistry
To establish an animal model for the controlled study of enteral nutrition by tube, five adult chair‐adapted primates ( Macaca fasicularis) had gastrostomy and jejunostomy tubes placed for the delivery of a modified protein isolate diet. Following 7 days of postoperative depletion with a hypo‐caloric infusion of dextrose (20 kcal, 0 g N/kg/day), the animals were repleted for 10 days with tube feedings (124 kcal, 0.73 g N/kg/day). There was no operative mortality or morbidity and each animal demonstrated conversion to anabolism by significant weight gain, positive nitrogen balance, and net protein synthesis as determined by [ 15 N]glycine protein turnover rates. Significant correlation was found between caloric intake and nitrogen balance at the level of nitrogen provided in this diet (r = 0.88, p < 0.05). This model was found to be well suited for the surgical and nutritional techniques required for the long‐term study of enteral nutrition by tube.