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Serum‐Sulfated Lithocholate as an Indicator of Cholestasis During Parenteral Nutrition in Infants and Children
Author(s) -
Farrell Michael K.,
Balistreri William F.,
Suchy Frederick J.
Publication year - 1982
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/014860718200600130
Subject(s) - cholestasis , parenteral nutrition , medicine , gastroenterology , bilirubin
Serum‐sulfated lithocholate concentrations were followed in 55 patients receiving parenteral nutrition. Elevation of serum lithocholate occurred in 18 (10/34 under 6 months of age, 8/21 older than 6 months). Serum sulfated lithocholate concentrations were a more sensitive indicator of cholestasis than either direct bilirubin or aminotransferases. The serum lithocholate concentrations in parenteral nutrition‐associated liver disease were similar to those seen in patients with known cholestasis.